HIV Reverse Transcriptase

A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.

Also Known As:

Reverse Transcriptase, HIV; Reverse Transcriptase, Human Immunodeficiency Virus; Transcriptase, HIV Reverse

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Phosphotransferases: 43773
      - Nucleotidyltransferases: 31
        DNA Nucleotidyltransferases: 4
        DNA-Directed DNA Polymerase: 1736
        RNA-Directed DNA Polymerase: 8903
        HIV Reverse Transcriptase: 79
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Viral Proteins: 4356
    - Viral Structural Proteins: 173
      - Nucleocapsid Proteins: 774
        Viral Core Proteins: 50
        pol Gene Products: 38
        RNA-Directed DNA Polymerase: 8903
        HIV Reverse Transcriptase: 79
        Human Immunodeficiency Virus pol Gene Products
        HIV Reverse Transcriptase: 79
    - Viral Nonstructural Proteins: 72
      - Viral Replicase Complex Proteins: 5
        pol Gene Products: 38
        RNA-Directed DNA Polymerase: 8903
        HIV Reverse Transcriptase: 79
        Human Immunodeficiency Virus pol Gene Products
        HIV Reverse Transcriptase: 79
    - Retroviridae Proteins: 7
      - Human Immunodeficiency Virus Proteins: 146
        Human Immunodeficiency Virus pol Gene Products
        HIV Reverse Transcriptase: 79
      - pol Gene Products: 38
        RNA-Directed DNA Polymerase: 8903
        HIV Reverse Transcriptase: 79
        Human Immunodeficiency Virus pol Gene Products
        HIV Reverse Transcriptase: 79

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Disease

Drug/Important Bio-Agent (IBA)